ELOVL1 Rabbit Polyclonal Antibody – AP01399PU-N


CAT#: AP01399PU-N
ELOVL1 rabbit polyclonal antibody, Aff - Purified

Product Data

Applications: WB

Recommended Dilution: Western Blots: 1/500-1/1000.

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Specificity: ELOVL1 antibody detects endogenous levels of ELOVL1 protein. (the region surrounding Phe139)

Formulation: Phosphate buffered saline (PBS), pH~7.2 containing 0.05% Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)

Concentration: 1.0 mg/ml

Purification: Affinity Chromatography using epitope-specific immunogen

Conjugation: Unconjugated

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.

Stability: Shelf life: one year from despatch.

Predicted Protein Size: ~35 kDa

Gene Name: Homo sapiens ELOVL fatty acid elongase 1 (ELOVL1), transcript variant 1

Background: Elongation of very-long-chain fatty acid-like (ELOVL) proteins 1-6 are members of the ELO family of proteins, which play an important role in tissue-specific biosynthesis of very-long-chain fatty acids and sphingolipids. The ELOVL proteins act as catalysts in fatty acid elongation reduction and localize to the endoplasmic reticulum (ER). Elongation of very long-chain fatty acids protein 1 (ELOVL1), also referred to as Ssc1, is the human homolog of the yeast ELO3 protein. It is expressed in a variety of tissues and at especially high levels in the stomach, skin, intestine, kidney, and lung. ELOVL1 participates in the elongation of very long-chain saturated and monounsaturated fatty acids of up to 26 carbons and may be required for the development of a barrier in epithelial cells and skin. ELOVL1 is also important for the formation of Myelin in the central nervous system. Impaired ELOVL1 activity may be associated with disorders of sphingolipid metabolism.

Synonyms: SSC1, CGI-88

Reference Data

Protein Families: Transmembrane